Pyxis™
High-Resolution, Real-Time Phenotypic Metabolomics

Real Time Biological
Insight for Bioprocessing
The Matterworks Pyxis Platform generates real-time biological insights for bioprocess applications through the absolute quantitation of up to 150 analytes fundamental to the metabolic pathways involved in protein synthesis, biomass production, cellular respiration, and protein glycosylation. These measurements provide a unique, mechanistic understanding of the biological and process-related factors driving product quantity and quality.
High-Resolution, Real-Time Phenotypic Metabolomics

Up to 150 Metabolites
From critical nutrients to intracellular metabolic intermediates to waste products; Pyxis provides a complete view of cell metabolism with up to 150 metabolites across central carbon metabolism and associated pathways.

Absolute Quantitation
The Matterworks technology platform is designed for absolute quantitation of metabolites in cell culture media and cell lysates, providing unparalleled data quality in a scalable metabolomics solution.

Rapid Results
With a 5-minute method and streamlined data analysis Pyxis is built for at-line process feedback and the throughput needed to complement complex experiments with deep metabolomics insights.
Get Started Fast

Consumables
Matterworks kits contain everything you need to get started. Simply plate your samples and add the Matterworks universal calibrators to your samples and you’re ready to go.

LC-MS Methods
We’ve done the method development and validation for you. Pyxis was developed to seamlessly integrate with existing LC-MS technology.

Rapid Results
No peak picking or curve integration, Pyxis transforms raw MS data into concentration automatically, allowing you to focus on the insight your data offers.

MS Quantitation Without MS Method Development
Pyxis combines mass spectrometry with advanced AI to generate absolute metabolite concentrations calculated within minutes through our cloud-based software. The platform of reagents and software integrate seamlessly with existing LC-MS instruments, without the need for method development or manual calibration curve creation. Using Pyxis, LC-MS acquisition time is dramatically reduced to approximately 5 minutes per sample, with absolute metabolite concentrations calculated within minutes through our cloud-based software.

Get Started with Pyxis
Pyxis has successfully demonstrated correlation to existing metabolomic measurements with samples generated by our alpha collaborators. The beta release for Pyxis is scheduled for early 2023 and full commercialization for mid 2023. Sign up now to learn more or to become one of our select beta testers.
Matterworks Applications
Therapeutic
Proteins
Whether you're developing a new product or scaling up an existing one, Pyxis gives you mechanistic insight into the factors influencing cell specific productivity and the critical quality attributes of your protein therapeutic.
Viral
Vector
Looking to scale your viral vector production process? Pyxis enabled metabolomics gives you a new tool for driving increases in viral yields.